Biochemical role of zinc in vivax malaria

Introduction and Aim: Zinc is a micronutrient that has significant immune modulatory function, its deficiency known to increase the risk of plasmodium infection in humans Although inflammatory processes contribute elimination plasmodium, persistent inflammation underlying cause malaria pathology. Cholinesterases are carboxypeptidases zinc dependent indicators low-grade inflammation. Plasma butyryl cholinesterase, biomarker dietary status zinc. Matrix metalloproteinases (MMP) endopeptidases contain which take part reactions. They participate remodeling extracellular matrix aid tissue repair. The current investigation aims study association these metalloproteins with patients vivax malaria. Materials methods: zinc, butyrylcholinesterase (BChE) erythrocyte acetylcholinesterase (AChE) were estimated spectrophotometrically 100 50 healthy subjects. MMP9 was determined using ELISA. Results: markedly lower compared controls (p<0.05). Both BChE AChE decreased significantly (p<0.00) There an elevation malaria, although statistically insignificant. correlated positively showed positive correlation (r=0.405, p=0.05). Conclusion: highlights role pathology as it essential for maintenance several enzyme activities. Further, prompt administration micronutrients like may reduce related morbidity